Acupuncture, particularly as an adjunctive therapy, shows promise for managing symptoms of Polycystic Ovary Syndrome . current high-quality evidence is definitively confirm its effectiveness for primary outcomes like live birth rates. Research suggests it helps regulate hormones and improve metabolic indicators with minimal side effects. Potential Benefits Clinical evidence and meta-analyses suggest that acupuncture may offer several benefits for women with PCOS: Hormonal Regulation: Acupuncture has been shown to significantly reduce levels of luteinizing hormone and testosterone, and improve the LH follicle-stimulating hormone ratio, helping to correct the hormonal imbalances characteristic of PCOS. Menstrual Cycle Improvement: Studies indicate that acupuncture can promote the recovery of regular menstrual cycles. Improved Ovulation and Pregnancy Rates: When used as an adjunct to conventional medications like letrozole or clomiphene, some studies suggest acupuncture can significantly increase ovulation and pregnancy rates compared to medication alone. One specific study found that adding acupuncture to letrozole treatment nearly doubled the pregnancy rate. Metabolic Health: Acupuncture may help attenuate insulin resistance (IR), decrease fasting blood glucose and insulin levels, and reduce body mass index in women with PCOS. Improved Endometrial Receptivity: Research indicates that acupuncture may improve uterine blood flow and endometrial lining, potentially enhancing the chances of embryo implantation. Emotional Well-being: Acupuncture may alleviate associated symptoms like anxiety and depression by regulating neurotransmitter levels. Mechanisms of Action Acupuncture is believed to work through several physiological mechanisms: Neuroendocrine Modulation: It is thought to modulate the hypothalamic-pituitary-ovarian axis and the hypothalamic-pituitary-adrenal axis by affecting the production of beta-endorphins and other neuropeptides, which in turn influences the release of GnRH, LH, and FSH. Insulin Sensitivity: It can activate signaling pathways involved in glucose metabolism, thereby enhancing insulin sensitivity. Blood Flow: Acupuncture may increase blood flow to the ovaries and uterus.