Acupuncture & mental Health Acupuncture help ease depression symptoms, as well as treat the underlying condition, although more research is needed to confirm. ... Both men and women in this study showed significant improvement after 4 weeks of acupuncture treatment. How do I know if my acupuncture treatment is working? Your pain will change. The key word here is change: change in location, severity, or intensity. ... Your sleep could improve (or change) ... Your mood will improve. ... You'll be more aware of your body. ... You'll have more energy.